Mounjaro, Zepbound, Compound Tirzepatide Side Effects and Remedies

Mounjaro Zepbound Compound Tirzepatide Side Effects & Remedies

Side effects are always the unpleasant side of medications and there certainly can be side effects on Mounjaro, Zepbound, or compound tirzepatide. These side effects can range from mild to quite extreme depending on how your body responds to the medication. It is a good rule of thumb to reach out to your provider if you have any concerns and to keep your provider updated about the side effects you are experiencing. I am currently in the middle of my journey with compound tirzepatide and have experienced some side effects, but have also found some remedies that make me feel much better. In this post, we will look at some of the common side effects of Mounjaro, Zepbound, and compound tirzepatide and also discuss some remedies. 


Nausea is common on this medication and can peak the days immediately following your shot. Keeping your meals small, avoiding fried, sugary, or fatty foods, and drinking lots of water are natural ways to help with this. If your nausea is interfering with everyday life, you may want to ask your doctor for a Zofran prescription. Keep in mind though, that Zofran can make constipation worse. 


Tirzepatide slows gastric emptying, which can lead to indigestion. Stomach pain, heartburn, and burping can all come from this. Remember to keep your meals small, avoid foods that are hard to digest, and drink your liquids. Over-the-counter Tums are ok to take. 


Constipation is common on tirzepatide. Eating a high-fiber diet and drinking lots of water can help. If you have trouble getting your fiber in because of your calorie deficit, consider a fiber bar or drink. Stool softeners can also be helpful and are typically much more gentle than laxatives. 


Diarrhea can happen on tirzepatide and watching your diet is probably the best way to avoid this. Don’t stuff yourself and make sure what you are eating will not trigger stomach upset. If you do experience diarrhea, make sure to stay hydrated and consider drinking an electrolyte drink. 


Fatigue is often experienced on tirzepatide. Making sure that you are eating and drinking enough, drinking an electrolyte drink, and supplementing with vitamins can all be helpful. My doctor told me to make sure I am eating at least 1,200 calories a day and if I do not hit that for some reason, I notice my fatigue being much worse. Make sure you are getting enough nutrients in, even if you do not feel very hungry. An afternoon nap can help with daily fatigue if you are able to fit it into your day. 


Many report headaches while on the meds. Drinking an electrolyte drink, having plenty of water, making sure you are getting enough calories, and prioritizing rest can all be helpful. Over-the-counter painkillers are ok to take. Be sure to talk to your doctor if your headache becomes severe. 

Hair Loss

Hair loss can be common likely because of the reduction in nutrition that goes along while on the medications. Supplementing with vitamins and collagen can help with this. 

Injection Site Pain

Injection site pain is bothersome to some. Many find injection in the thigh hurts less than the stomach or arm. Experiment with the different injection sites and if a certain area is more comfortable for you. Over-the-counter painkillers are ok to take if you have some soreness. 


Since side effects often peak the days following your shot, consider being strategic about your shot day. For example, if you take your shot on a Thursday night, your side effects may peak on the weekends when you can rest more. Try to give yourself grace while on this medication and listen to your body. Take it easy when your body is telling you it needs rest and provide it with enough nutrition to keep going. Side effects can increase when you titrate up your dose and lessen as your body gets used to the medication.

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